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Prior studies have demonstrated that estrogen negatively regulates growth hormone (GH) signaling by activating SOCS-3 to inhibit JAK/STAT signaling and has been shown to reduce insulin-like growth factor (IGF)-1 levels by 40% to 80% in healthy adult men with intact pituitary function [4, 5]

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Higher intakes of the compound spermidine from the diet have been associated with a lower incidence of cognitive decline, but does taking spermidine have this benefit